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PKC1 expressed in the proximal tubule is critical for inducing the expression of transforming growth factor-1 (TGF1), which is an essential mediator of the switch from proliferation to hypertrophy in renal proximal tubular cells during the early stage of DKD through the extracellular signal-regulated kinase (ERK) and p38 pathway

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Existing reviews have further highlighted that pharmacokinetic and safety characterization in humans remains incomplete, complicating clinical counseling regarding timing of discontinuation, perioperative risk stratification, and postoperative resumption (Rahman et al